JOURNAL OF PHARMACOLOGY AND
BIOMEDICINE
ISSN.2456-8244
Epilepsy, a prevalent neurological disorder, necessitates the con- tinuous search for novel therapeutic strategies, particularly for drug-resistant cases. Benzotriazole, a versatile heterocyclic scaf- fold, has garnered significant attention in medicinal chemistry due to its diverse pharmacological activities, including anticonvulsant properties. This review synthesizes the latest research on benzo- triazole derivatives in epilepsy, focusing on preclinical investiga- tions over the last five years. The article explores the efficacy of these compounds in various animal models of seizures, highlight- ing promising results in maximal electroshock, pentylenetetrazole, and kindling models. Potential mechanisms of action, such as modulation of GABAergic neurotransmission, blockade of sodium channels, and kappa-opioid receptor agonism, are discussed. Fur- thermore, the review delves into structure-activity relationship studies, elucidating the impact of specific structural modifications on anticonvulsant activity. Emerging trends, including the devel- opment of multi-target ligands and greener synthetic methodolo- gies, are also examined. While preclinical findings are encourag- ing, the review addresses the challenges in translating these com- pounds to clinical use, including bioavailability, safety, and drug resistance. The potential clinical relevance of benzotriazole deriva- tives in epilepsy treatment is considered, emphasizing the need for further translational research to fully unlock their therapeutic potential for this debilitating condition.
NAMES:
ONLINE ISSN:2456-8244
Keywords: Epilepsy, Benzotriaozle, Structure Activity Relationship, GABA, Clinical Trials
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