JOURNAL OF PHARMACOLOGY AND
BIOMEDICINE
ISSN.2456-8244
The main aim of the study was to formulate, optimize, evaluate topical preparation of Allicin gel and determine antibacterial prop- erties. Allicin is an organosulfur compound used in the treatment of bacterial skin infections. Total six formulations (F1, F2, F3, F4, F5 & F6) were formulated by using different concentration of al- licin with carbopol 934 and determine antibacterial property against gram positive bacterias - Staphylococcus Aureus, Bacillus Cereus, Streptococcus Mutans and Streptococcus Gordonii. The results reveal that the study was within acceptable limits as per the ICH guidelines. Formulated gels were homogenized and stable. Topical application of the herbal gel F6 containing 0.6 mg conc of allicin showed better release (78.2%) with significant antibacterial properties against three bacteria’s i,e. Bacillus Cereus, Streptococ- cus Mutans and Streptococcus Gordonii.
NAMES:
ONLINE ISSN:2456-8244
Keywords: Allicin, Antibacterial property, Carbopol 934, Gram positive bacteria, Ultra-Centrifugation, Homogenization
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