Journal Logo
JOURNAL OF PHARMACOLOGY AND BIOMEDICINE
ISSN.2456-8244
Editor-in-Chief
Dr.Richa Mishra Online ISSN
2456-8244 Publisher
RB-Science Abbreviation
J. Pharmacol. Biomed
ABSTRACT

The leading cause of death in the world today is cancer. The re- sults of cancer patients have significantly improved with the devel- opment of surgery, radiotherapy, and pharmaceuticals. Cancer's basic mechanisms, nevertheless, are still poorly understood. Natu- ral remedies have recently been demonstrated to be helpful for a number of ailments and have been crucial in the development of innovative therapies. A significant body of research indicates that bioactive substances may benefit cancer patients' prognoses through a number of routes, including endoplasmic reticulum stress, epigenetic alteration, and oxidative stress reduction. Here, we discuss the most recent research on bioactive substances found in natural products for the treatment of cancer and provide an overview of the pathological process' underlying mechanisms.

Articles Details

NAMES:

ONLINE ISSN:2456-8244

Keywords: Bioactive compounds, Molecular mechanism, Polyphenols, Phenolic acids, Cancer

DOI:

REFERENCES

1. Bray, F.; Ren, J.; Masuyer E., Ferlay, J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int. J. 
Cancer. 2013,2,132:1133–1145. doi: 10.1002/ijc.27711 
2. Menter,T.; Tzankov,A.;Dirnhofer. “The tumor microenvironment of lymphomas: insights into the potential role and modes of actions of 
checkpoint inhibitors. Hematological Oncology. 2021,39, 3–10. 
3. Logan,J.; Bourassa,M. The rationale for a role for diet and nutrition in the prevention and treatment of cancer. European Journal of Can-
cer Prevention. 2018,27,  406–410. 
4. Garcia-Martinez,O.; Ruiz,C.; Gutierrez-Ibanez,A.;  Illescas-Montes. Benefits of olive oil phenolic compounds in disease preven-
tion. Endocrine, Metabolic & Immune Disorders Drug Targets. 2018, 18, 333–340. 
5. Nwachukwu,D.; Aluko. Structural and functional properties of food protein-derived antioxidant peptides. Journal of Food Biochem-
istry.2019, 43,12761. 
6. Nongonierma,B.; FitzGerald. Enhancing bioactive peptide release and identification using targeted enzymatic hydrolysis of milk pro-
teins. Analytical and Bioanalytical Chemistry. 2018, 410, 3407–3423. 
7. Wada,Y.; Lönnerdal. Bioactive peptides derived from human milk proteins: an update. Current Opinion in Clinical Nutrition and 
Metabolic Care. 2020,23, 217–222. 
8. Fantini,M.; Benvenuto,M.; Masuelli . In vitro and in vivo antitumoral effects of combinations of polyphenols,or polyphenols and anti-
cancer drugs: perspectives on cancer treatment. International Journal of Molecular Sciences. 2015,16, 9236–9282. 

9. Thyagarajan, A.;  Forino,S.;  Konger,   pancreatic cancer, Antioxidants,2020,  9,  651.  
10. Dietary polyphenols in cancer chemoprevention: implications. 
11. Lu,J.;N. Panchanathan, R.; Lee, W.; Kim, J.; Kim . Anthocyanins from the Fruit of Vitis Coignetiae Pulliat Inhibit TNF-Augmented Can-
cer Proliferation, Migration, and Invasion in A549 Cells. Asian Pac. J. Cancer Prev. 2017,18,2919.  
12. Cojocneanu Petric, R.; Braicu, C.; Raduly, L. Phytochemicals modulate carcinogenic signaling pathways in breast and hormone-related 
cancers. O nco tar ge ts and Therapy . 2015,8,2053–2066. 
13. Logan, J.; Bourassa, W. The rationale for a role for diet and nutrition in the prevention and treatment of cancer. European Journal of Can-
cer Prevention . 2018,27(4),406–410. doi: 10.1097/CEJ.0000000000000427. 
14. Shanmugam, M.; Kannaiyan, R.; Sethi, G. Targeting cell signaling and apoptotic pathways by dietary agents: role in the prevention and 
treatment of cancer. Nutrition and Cancer . 2011,63(2),161–173. 
15. Sung, H.; Ferlay, J.; Siegel, R. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 can-
cers in 185 countries. CA: a Cancer Journal for Clinicians . 2021,71(3),209–249. 
16. Aqil, F. Anti-proliferative activity and protection against oxidative DNA damage by punicalagin isolated from pomegranate husk. Food 
Research International. 2012,49(1),345-353 
17. Albrecht, M. Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. J Med 
Food. 2004, 7(3),274-283 
18. Clinton, S. Lycopene: Chemistry, Biology, and Implications for Human Health and Disease. Nutrition Reviews, 2009,56(2), 35–51 
19. DiMarco-Crook, C.; Xiao, H. Diet-Based Strategies for Cancer Chemoprevention: The Role of Combination Regimens Using Dietary 
Bioactive Components. Annual Review of Food Science and Technology.2015 
20. Faria, A.; Conceição, C. The bioactivity of pomegranate: Impact on health and disease. Critical Reviews in Food Science and Nutrition, 
2011,51(7), 626-634. 
21. Montané. X.; Kowalczyk. O.; Reig-Vano, B. Current perspectives of the applications of poly-phenols and flavonoids in cancer thera-
py. Molecules . 2020,25(15),3342. 
22. Sajadimajd. S.; Bahramsoltani. R.; Iranpanah, A. Advances on natural polyphenols as anticancer agents for skin can-
cer. Pharmacological Research . 2020,151 104584 doi: 10.1016/j.phrs.2019.104584  
23. Williamson, G.; Dionisi, F.;  Renouf, M. Flavanols from green tea and phenolic acids from coffee: critical quantitative evaluation of the 
pharmacokinetic data in humans after consumption of single doses of beverages. Molecular Nutrition & Food Research .2011,55, 864–
873. 
24. Nasrollah Jabbari. Inhibitory effects of gallic acid on the activity of exosomal secretory pathway in breast cancer cell lines: A possible 
anticancer impact. BioImpacts. 2022,12(6), 549-559. 
25. Ho Man Tang ,Peter Chi Keung Cheung. Gallic Acid Triggers Iron-Dependent Cell Death with Apoptotic, Ferroptotic, and Necroptotic 
Features. Toxins .2019, 11(9), 492; https://doi.org/10.3390/toxins11090492 
26. Vijaya Padma, V.; Sowmya, P.; Arun Felix, T.; Baskaran, R.; Poornima, P. Protective effect of gallic acid against lindane induced toxicity in 
experimental rats. Food Chem. Toxi-col. 2011, 49, 991–998. 
27. Chuang, C.Y.; Liu, H.C.; Wu, L.C.; Chen, C.Y.; Chang, J.T.; Hsu, S.L. Gallic acid induces apoptosis of lung fibroblasts via a reactive oxy-
gen species-dependent ataxia telangiectasia mutated-p53 activation pathway. J. Agric. Food Chem. 2010, 58, 2943–2951